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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorGonzález Miranda, Carlos J.
dc.contributor.authorMerced Vega, Yaritza
dc.date.accessioned2020-12-17T18:33:47Z
dc.date.available2020-12-17T18:33:47Z
dc.date.issued2019
dc.identifier.citationMerced Vega, Y. (2019). Wet granulation end-point determination of a drug formulation [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/1012
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractWet granulation is commonly used in oral solid dosage industry. The end-point is required to design a process that consistently meet products Critical Quality Attributes (CQAs) and the Critical Processing Parameters (CPPs). There are many methods available for end-point determination with their owns constraints of reproductivity and accuracy. Torque measurer was installed on the Low shear granulation and product “XA” was monitored. The results confirm that automated process provide better process control and reproducibility. Torque measurement demonstrate to be a reliable control method in relation to mass resistance. In order to determine wet granulation end-point the Project Management Institute (PMI®) methodology was used. PMI® comprise of five main steps in the process; initiating, planning, executing, monitoring and controlling, and closure. This research pursue to improve and determine the wet granulation end-point of a drug product. PMI® methodology brings a structure and the tool to identify and solve the problem. Key Terms ⎯ Automation, End-Point, Torque, Wet Granulation.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesWinter-2019;
dc.relation.haspartSan Juanen_US
dc.subject.lcshDrugs--Granulationen_US
dc.subject.lcshPharmaceutical industry
dc.subject.lcshExcipients
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Posters
dc.titleWet Granulation End-Point Determination of a Drug Formulationen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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