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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorNieves Castro, Rafael A.
dc.contributor.authorPérez Figueroa, Alexander G.
dc.date.accessioned2022-07-13T19:34:16Z
dc.date.available2022-07-13T19:34:16Z
dc.date.issued2022
dc.identifier.citationPérez Figueroa, A. G. (2022). Development of Dual Drugs with Coated Microneedles [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/1642
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractCoated microneedles have been shown to deliver biopharmaceuticals and drugs into the skin in a minimally invasive manner. To increase patient acceptance, smaller needle diameters and lower insertion forces have been investigated to reduce the frequency of painful injections. Guided by these, microneedles have been developed to minimize pain and are more useful for vaccine administration. This research was to develop a process for coating two different drugs with microneedles, make uniform coatings, and establish that the mass ratio of the components in the coating solution is maintained when measured in microneedles. The results shows that the drugs when in a pure state and with high concentration the absorbance tends to be higher but the absorbance decreases proportionally with the concentration of each substance when the drugs are mixed in different concentrations. When using the coating solution at different concentrations, absorbance varied but the mass ratio remained the same. Key Terms⎯ Coating solution, Dip-coated method, Microneedles, Ratioen_US
dc.language.isoenen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesSpring-2022;
dc.relation.haspartSan Juanen_US
dc.subject.lcshHypodermic needleen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Researchen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Postersen_US
dc.subject.lcshCoating processes
dc.titleDevelopment of Dual Drugs with Coated Microneedlesen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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