| dc.rights.license | All rights reserved | en_US |
| dc.contributor.advisor | Nieves Castro, Rafael A. | |
| dc.contributor.author | Marrero Vázquez, Michelle | |
| dc.date.accessioned | 2020-06-25T12:00:17Z | |
| dc.date.available | 2020-06-25T12:00:17Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Marrero Vázquez, M. (2018). Optimization of pharmaceutical product production lots at granulation manufacturing stage [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico. | en_US |
| dc.identifier.uri | http://hdl.handle.net/20.500.12475/207 | |
| dc.description | Design Project Article for the Graduate Programs at Polytechnic University of Puerto Rico | en_US |
| dc.description.abstract | The customer of ABD Company wants
the CY product to meet 7% 40 mesh requirement in
80% of the lots requested. The company has two
granulators that are used for the manufacturing of
the product but one of them typically produces
higher 40 mesh values than the other one. A project
to understand the situation was proposed and tools
from DMAIC methodology were used. It was found
out with the investigation that the granulator that
produced higher values had a different humidity
setpoint which caused more water to be needed in
the manufacturing process. It is understood that
coarser particles are a result of water excess. A
change in the humidity setpoint was recommended
as a solution of the problem and to harmonize both
equipment. Once the change is implemented it
should be monitored to see the results after the
change.
Key Terms - DMAIC, Granulation,
Improvements, Pharmaceutical Industry. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Polytechnic University of Puerto Rico | en_US |
| dc.relation.ispartof | Manufacturing Engineering | |
| dc.relation.ispartofseries | Fall-2018 | |
| dc.relation.haspart | San Juan Campus | en_US |
| dc.subject.lcsh | Six sigma (Quality control standard) | |
| dc.subject.lcsh | Pharmaceutical industry--Quality control | |
| dc.subject.lcsh | Polytechnic University of Puerto Rico--Graduate students--Research | |
| dc.subject.lcsh | Polytechnic University of Puerto Rico--Graduate students--Posters | |
| dc.title | Optimization of pharmaceutical product production lots at granulation manufacturing stage | en_US |
| dc.type | Article | en_US |
| dc.rights.holder | Polytechnic University of Puerto Rico, Graduate School | en_US |
