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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorNieves Castro, Rafael A.
dc.contributor.authorMarrero Vázquez, Michelle
dc.date.accessioned2020-06-25T12:00:17Z
dc.date.available2020-06-25T12:00:17Z
dc.date.issued2018
dc.identifier.citationMarrero Vázquez, M. (2018). Optimization of pharmaceutical product production lots at granulation manufacturing stage [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/207
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractThe customer of ABD Company wants the CY product to meet 7% 40 mesh requirement in 80% of the lots requested. The company has two granulators that are used for the manufacturing of the product but one of them typically produces higher 40 mesh values than the other one. A project to understand the situation was proposed and tools from DMAIC methodology were used. It was found out with the investigation that the granulator that produced higher values had a different humidity setpoint which caused more water to be needed in the manufacturing process. It is understood that coarser particles are a result of water excess. A change in the humidity setpoint was recommended as a solution of the problem and to harmonize both equipment. Once the change is implemented it should be monitored to see the results after the change. Key Terms - DMAIC, Granulation, Improvements, Pharmaceutical Industry.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering
dc.relation.ispartofseriesFall-2018
dc.relation.haspartSan Juan Campusen_US
dc.subject.lcshSix sigma (Quality control standard)
dc.subject.lcshPharmaceutical industry--Quality control
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Posters
dc.titleOptimization of pharmaceutical product production lots at granulation manufacturing stageen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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