• 1x16 Post Weld Continuity 

      Martínez Adorno, Valerie (Polytechnic University of Puerto Rico, 2021)
      Laser welding is a critical process of medical device used for the manufacturing process of spinal cord stimulation leads that brings different offenders. The highest for 1x16 family is ...
    • 5s Techniques to Optimize Classroom Organization 

      Moreno López, Stephanie L. (Polytechnic University of Puerto Rico, 2020)
      This research project was focused in the 5s methodology for the improvement of an elementary classroom. The 5s is defined as a method of five steps that seeks to improve working space, eliminate waste and improve ...
    • Analytical Method Technology Transfer From Quality Control Laboratory To Manufacture Area 

      Pérez Dominicci, Linnette (Polytechnic University of Puerto Rico, 2021)
      The project was developed with the intent to document the analytical transfer method to reduce in-process concentration testing cycle time. A reduction of up to 50% turnaround time (TAT) downtime was achieved. Waste reduction ...
    • Application of Lean Manufacturing and Lean Six Sigma Tools to Improve Back to Back Activities in the Compression Process 

      Calzada Vázquez, Omar (Polytechnic University of Puerto Rico, 2019)
      A recent opportunity regarding a product ramp up in the production schedule due to a potential product transfer requires the manufacturing area to look for creative ways to improve in order to comply with expected ...
    • Application of Six Sigma DMAIC methodology in a Merchandise Receiving Process at Burlington Store 

      Marrero-Santiago, Wilmarie (Polytechnic University of Puerto Rico, 2021)
      With the intent of decreasing the cycle time of the merchandise process receiving, the unloading and scanning step and the sorting step were identified as a labor cost opportunity. Through 3 kaizen events done across site, ...
    • Audit Process Optimization in the Manufacturing Area 

      Ortiz Martinez, Alexander (Polytechnic University of Puerto Rico, 2021)
      This project was developed to demonstrate a viable audit process optimization in the manufacturing area. The AbbVie site ubicated in Barceloneta, Puerto Rico,started with only one product back in ...
    • Automatización Y Optimización Del Garaje Rivera 

      Torres Soto, Dorian E. (Polytechnic University of Puerto Rico, 2020)
      Este trabajo consiste en el desarrollo de un mecanismo que pueda ser utilizado con fines de documentación. Se efectuará en un taller de mecánica en el cual se busca automatizar y optimizar diferentes partes del proceso. ...
    • Buffer Formulation Vent Filter Re-Use at Parenteral Manufacturing Plant 

      Figueroa-Rodríguez, Jorge (Polytechnic University of Puerto Rico, 2020)
      For sterilization-in-place cycles that used vent filters as a redundant non-contact product, the filter membranes could be re-used several times without impacting their integrity neither compromising the sterilization ...
    • Carnauba Dispenser to Improve Coated Tablets Elegance 

      Negrón Romero, Mara Liz (Polytechnic University of Puerto Rico, 2021)
      This study describes the implementation of Six Sigma for improvement of the addition process of carnauba wax on coated tablets in a pharmaceutical industry. Due to the frequent complaints received from costumers for covered ...
    • Catheter bonding Process Improvements with High-intensity Ultraviolet Curing Systems 

      Ortega Meléndez, María del Mar (Polytechnic University of Puerto Rico, 2021)
      Ultraviolet (UV) curing is a common process used in medical devices manufacturing for bonding operations. Light-curable adhesives provide rapid cure, great adhesion, and good chemical resistance for sterilization processes. ...
    • Change Control Routed with Missing Information Delaying Approval and Implementation Date 

      Álvarez Rodríguez, Bianca (Polytechnic University of Puerto Rico, 2022)
      The approval of manufacturing change control for MedDevice Inc., is currently acting lower than target(15 business days). Based on a 12-months data review, the lead time of approval of a change is approximately ...
    • Changeover Reduction Time by Adjusting the Cleaning Critical Parameters in Automated CIP Systems 

      Garay Charleman, Lynnette (Polytechnic University of Puerto Rico, 2018)
      Clean-In-Place (CIP) is a widely use process to clean biotechnology vessels contact surfaces. CIP is an automated cleaning method that involve minimum to no equipment disassembling thereby reducing labor and time ...
    • Chromatography Skid 3 Automation Integration Layer Upgrade 

      Figueroa Agosto, Delianne N. (Polytechnic University of Puerto Rico, 2023)
      This research will focus on upgrading the Chromatography System 3 to reduce time and generate batch reports. In this way, system monitoring is more effective and documentation is more accurate. The system handles an excessive ...
    • Clean in Place Recipe Optimization 

      Marin Alvarez, Crystal (Polytechnic University of Puerto Rico, 2021)
      This improvement project was based in reduce the fixed tanks and transfer lines Clean in Place (CIP) recipe execution by consolidating the Water for Injection (WFI) rinse and the WFI CIP recipes into one single recipe. ...
    • Cleaning Validation of a Manufacturing Line using CIP-100 Detergent and a Clean-in-place Skid System 

      Rivera Barreto, Deanceshka A. (Polytechnic University of Puerto Rico, 2022)
      Cleaning Validation is a prime element of control to the cross contamination and potential carry over topic at the manufacturing industry. This process must assure the quality, safety and efficiency of cleaning ...
    • Coating Process Improvement 

      Santos Pirela, Lorraine (Polytechnic University of Puerto Rico, 2021)
      An increase in the number of events associated to AQLfailure that resulted on partial batch rejections was observed in 2020 for Tablets/Caplets formulations due to cosmetic conditions ...
    • Control licenses area optimization 

      García Beato, Iris Anel (Polytechnic University of Puerto Rico, 2019)
      When working in a company that contains processes regulated by state and federal agencies, any task performed by staff is critical. Especially when the company supplies products that are consumed by people. A controlled ...
    • Controlled Environmental Area Room B Relayout for Acuity X4 Subassemblies Manufacturing Line Transfer 

      Ramírez Quiles, Ashley (Polytechnic University of Puerto Rico, 2021)
      Boston Scientific is part of a competitive environment and strives to find methods to reduce cost, waste and improve quality. A methodology for reduction is Lean manufacturing. This methodology is used to reduce “muda” ...
    • Cost Improvement Tracking System to Promote a Stream Lined Program 

      Ramos Morales, Luis Rene (Polytechnic University of Puerto Rico, 2022)
      This project presents the development of a process supported by a technology mechanism to facilitate the tracking and management of programs implemented by organizations to lower the cost base and/or promote ...
    • COVID-19 as a Stimulus for Remote Manufacturing Efforts 

      Montano Caraballo, Giselle B. (Polytechnic University of Puerto Rico, 2020)
      The Island of Puerto Rico currently encounters the same issue as the rest of the world but does not count with the proper technology in manufacturers to confront it Remote operations of manufacturing systems are needed ...