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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorGonzález Miranda, Carlos J.
dc.contributor.authorAponte Medina, Edneris
dc.date.accessioned2020-10-22T14:10:58Z
dc.date.available2020-10-22T14:10:58Z
dc.date.issued2013
dc.identifier.citationAponte Medina, E. (2013). Anti-inflammatory drug elution rate variability reduction [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/886
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractThis project was focused in the Drug Elution Rate Variability of an Anti-inflammatory Drug used in a Medical Device Company. The project is based on the manufacturing and bonding process of a DXA Drug Collar that is a component of a lead manufacturing company. As part of the Lot Acceptance testing for drug collars, elution testing is performed. Results must comply both individual and mean values in order to be considered acceptable. A failure in a drug collar lot could result in a cost of scrapping or a field action. Therefore, there is a need to implement changes that reduce the variability of the elution testing. The methodology selected for this project is DMAIC. A process map will be developed to identify elements that could be providing variability in elution rate and provide recommendations for manufacturing process enhancement. An implementation plan will be create for proposed changes implementation. Key Terms - DMAIC (Define, Measure, Analyze, Implement, Control), DXA (Dexamethasone Acetate), FDA (Federal Drug Administration), Lot Acceptance Test.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesSpring-2013;
dc.relation.haspartSan Juanen_US
dc.subject.lcshMedical instruments and apparatus industry--Quality control
dc.subject.lcshManufacturing processes--Quality control
dc.subject.lcshSix sigma (Quality control standard)
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleAnti-inflammatory Drug Elution Rate Variability Reductionen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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