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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorNieves Castro, Rafael A.
dc.contributor.authorMarrero Teruel, Cruz M.
dc.date.accessioned2020-11-04T12:45:38Z
dc.date.available2020-11-04T12:45:38Z
dc.date.issued2009
dc.identifier.citationMarrero Teruel, C. M. (2009). Optimization of on-line automated dissolution system for solid dose control release tablets [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/933
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractAbstract ⎯ An optimization of an automated dissolution system for control release tablets has been accomplished by the implementation of several variables using Six Sigma tools. Variables under evaluation includes: filter retention, baselines verification and addition of system suitability parameters. The implementation of the analyzed variables were compare before and after the optimization within 95% confidence interval generating statistically difference between them for three (3) out of four (4) sampling points. Additionally, after the statistical evaluation of the changes the dissolution profiles were evaluated by dissolution similarity factor (f2) test, where the improvements shows an increase of fifteen (15) units against the same test before the implementation of the optimization. Key Terms ⎯ Control Release Tablets, Dissolution profile, UV/VIS Spectroscopy.en_US
dc.language.isoenen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Compretitiveness;
dc.relation.ispartofseriesSpring-2009;
dc.relation.haspartSan Juanen_US
dc.subject.lcshSix sigma (Quality control standard)en_US
dc.subject.lcshPharmaceutical industry--Quality controlen_US
dc.subject.lcshManufacturing processes--Automationen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleOptimization of On-Line Automated Dissolution System for Solid Dose Control Release Tabletsen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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