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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorTorres, Edgar
dc.contributor.authorAlvelo Ortiz, Grisel
dc.date.accessioned2020-12-15T13:40:53Z
dc.date.available2020-12-15T13:40:53Z
dc.date.issued2010
dc.identifier.citationAlvelo Ortiz, G. (2010). Design of a cleaning change over reduction strategy for a high volume product in a packaging line [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/989
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractCurrently packaging operations are trying to reduce the downtime and operational cost among others activities to enhance efficiency and overall process performance. Based on this objective, pharmaceutical packaging operations defined, proved and validated a process that allowed to use five released bulk lots be combined into one packaging lot. The strategy proved to be efficient for operational cost, unproductive time reduction and cross contamination. An identified disadvantage was that if a quality event was noticed in the release product, no bulk segregation could be done. Once each bulk lot is added into the filler machine or product bottle, it was mixed with previous bulk lots and it cannot be determined which tablet belongs to a specific bulk. Redesigned batch record includes a table to estimate the bulk traceability when it is packaged as Combolot. A project to develop a sub-lot numbering system was identified as future wok for this research. Key Terms ⎯ Cleaning validation, campaign, change over, combined lots, packaging lots, process improvements.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesSpring-2010;
dc.relation.haspartSan Juanen_US
dc.subject.lcshPackagingen_US
dc.subject.lcshSix sigma (Quality control standard)
dc.subject.lcshCleaning
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleDesign of a Cleaning Change Over Reduction Strategy for a High Volume Product in a Packaging Lineen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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