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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorGonzález Miranda, Carlos J.
dc.contributor.authorJoshi Sánchez, Atika N.
dc.date.accessioned2020-09-17T13:38:21Z
dc.date.available2020-09-17T13:38:21Z
dc.date.issued2014
dc.identifier.citationJoshi Sánchez, A. N. (2014). Downstream sampling process optimization [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/731
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractThe Downstream Sampling Process in the Biopharmaceutical industry is a timely and product consuming step. This process can be described as a highly labor intense due to all the required steps to collect a sample. In order to optimize the sampling process is important to maintain the product sample attributes. For this case these attributes were; pH conductivity, endotoxin and bioburden. The main objective of this project was the optimization of the product sampling process based on samples reduction, sterilization, and reducing the risk of product contamination by applying a six sigma methodology. PR Biotechnology Solutions Company challenged the capability of two inprocess sampling devices (MN and GSD). Finally, experiments results, showed that both sampling devices MN and GSD are capable to collect the in process samples from process tank without affecting the established process parameters or compromising the sterility of the sample. Key Terms – Downstream, Optimization, Product, Sampling.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesFall-2014;
dc.relation.haspartSan Juanen_US
dc.subject.lcshSix sigma (Quality control standard)
dc.subject.lcshSampling
dc.subject.lcshBiotechnology industries
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleDownstream Sampling Process Optimizationen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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