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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorCruzado Vélez, Héctor J.
dc.contributor.authorDelgado Rivera, Cristina
dc.date.accessioned2024-03-25T14:37:05Z
dc.date.available2024-03-25T14:37:05Z
dc.date.issued2020
dc.identifier.citationDelgado Rivera, C. (2020). Optimization of the Induction Solutions Preparation and Addition Process in Bulk Manufacturing at a Biopharmaceutical Plant [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/2333
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractAn optimization of the induction solutions manufacturing and addition processes, used during the protein generation in a Cell Culture process is pursued at a Biopharmaceutical plant located in Juncos, Puerto Rico. Initiatives to improve the Cell Culture process are desired due to its extent, complexity, risks, and associated costs. The data collection for the project was segregated into two main areas: Media Preparation Area and Cell Culture Area; and focused on developing Process Flow Diagrams, Voice of the Customer (VOCs) exercises, durations analysis, and costs evaluations of the current processes. An optimized batch size of a combined induction solutions with High Temperature Short Time (HTST) treatment was implemented at the Media Preparation area; while in the Cell Culture area, a simplified addition process was implemented. The project achieved an increase in manufacturing capacity, implemented risk mitigation controls, reduced costs and man hours required for the addition process. Key Terms ⎯ cell culture optimization, continuous improvement, induction solutions addition, manufacturing competitiveness.en_US
dc.language.isoenen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManagement;
dc.relation.ispartofseriesFall-2020;
dc.relation.haspartSan Juanen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Researchen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Subject headings--Unassigneden_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Postersen_US
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate School--Master in Engineering Management degreeen_US
dc.titleOptimization of the Induction Solutions Preparation and Addition Process in Bulk Manufacturing at a Biopharmaceutical Planten_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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    Articulos y Carteles de investigación (Poster): Ingeniería Gerencial (MEM) [San Juan, INTEC], Gerencia Ambiental (MEnvM) y Administración de Empresas (MBA)

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