dc.rights.license | All rights reserved | en_US |
dc.contributor.advisor | González Miranda, Carlos J. | |
dc.contributor.author | Joshi Sánchez, Atika N. | |
dc.date.accessioned | 2020-09-17T13:38:21Z | |
dc.date.available | 2020-09-17T13:38:21Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Joshi Sánchez, A. N. (2014). Downstream sampling process optimization [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico. | en_US |
dc.identifier.uri | http://hdl.handle.net/20.500.12475/731 | |
dc.description | Design Project Article for the Graduate Programs at Polytechnic University of Puerto Rico | en_US |
dc.description.abstract | The Downstream Sampling Process in
the Biopharmaceutical industry is a timely and
product consuming step. This process can be
described as a highly labor intense due to all the
required steps to collect a sample. In order to
optimize the sampling process is important to
maintain the product sample attributes. For this
case these attributes were; pH conductivity,
endotoxin and bioburden. The main objective of
this project was the optimization of the product
sampling process based on samples reduction,
sterilization, and reducing the risk of product
contamination by applying a six sigma
methodology. PR Biotechnology Solutions
Company challenged the capability of two inprocess sampling devices (MN and GSD). Finally,
experiments results, showed that both sampling
devices MN and GSD are capable to collect the in
process samples from process tank without
affecting the established process parameters or
compromising the sterility of the sample.
Key Terms – Downstream, Optimization,
Product, Sampling. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Polytechnic University of Puerto Rico | en_US |
dc.relation.ispartof | Manufacturing Engineering; | |
dc.relation.ispartofseries | Fall-2014; | |
dc.relation.haspart | San Juan | en_US |
dc.subject.lcsh | Six sigma (Quality control standard) | |
dc.subject.lcsh | Sampling | |
dc.subject.lcsh | Biotechnology industries | |
dc.subject.lcsh | Polytechnic University of Puerto Rico--Graduate students--Research | |
dc.title | Downstream Sampling Process Optimization | en_US |
dc.type | Article | en_US |
dc.rights.holder | Polytechnic University of Puerto Rico, Graduate School | en_US |