• Improvement of Predictive Model to Reduce Impurity Presence Based on Raw Material Combination Pre-Selection 

  Nieves, William Loubriel (Polytechnic University of Puerto Rico, 2023)

  Biotechnology manufacture is composed of two main sections, Active Pharmaceutical Ingredient (API) and Drug Product (DP). The DS manufacturing most common steps are cell culture or fermentation (DSI), recovery and purification. ...

• Optimization of Bioburden Samples Processing in the Microbiology Laboratory Using Six Sigma 

  Rosa Matos, Raquel (Polytechnic University of Puerto Rico, 2023)

  This article presents the use of the Lean Six Sigma tool to identify factors affecting the processing of samples that require Bioburden testing in the Microbiology Laboratory. The objective of this article was to implement ...

• Improvement and Design of a Kitchen Using DMADV Methodology 

  Carradero Torres, Néstor (Polytechnic University of Puerto Rico, 2023)

  This design project will focus on remodeling a kitchen for an elderly person. The kitchen that is going to be remodeled has a peninsula or G-shaped layout design. The new design that will be introduced aims to save time ...

• Reduce Scrap for Kiefel Machine Non-PVC 

  Rivera Rivera, Natalia (Polytechnic University of Puerto Rico, 2023)

  The bag-making process is performed in different locations globally. IV Bags are used worldwide for various treatments. This project aims to reduce the scrap from the Non-PVC machine. This is the only one of ten department ...

• Manufacturing of a Continuous Line of Salbutamol Tablets Through the Methodology of DMADV 

  Santiago Rodríguez, Michael (Polytechnic University of Puerto Rico, 2023)

  This project aimed to enhance the production process of salbutamol by designing and implementing a continuous production line using the DMADV methodology. The study objectives were to establish proper visualization of the ...

• Construction Services Company – Purchases Process and Warehouse System Improvements 

  Rivera Santiago, Luis E. (Polytechnic University of Puerto Rico, 2023)

  In the manufacturing industry, engineers focus on positively impacting all areas related to product output. When the output is tangible, several methodologies and assessments can be implemented to improve the production ...

• Product Mix Analysis in Manufacturing Line 

  Mercado López, Josean (Polytechnic University of Puerto Rico, 2023)

  This research project was focused on the Product Mix Analysis of a Medical Device manufacturing line due to a customer complaint. A product mix is a manufacturing defect and is defined as a mix of components/ assembly ...

• Sistema de Validación, Comisionar y Cualificar en la era Digital 

  Tejada González, Gennesis B. (Polytechnic University of Puerto Rico, 2023)

  Este proyecto es basado en la investigación creación de documento dentro una nueva de la nueva implementación de un programa para la validación digital en las industrias de BioFarma y Medical Device. Esta nueva plataforma ...

• IV Bag Fill Volume Project 

  Bello Santiago, Félix E. (Polytechnic University of Puerto Rico, 2023)

  Accurate filling of intravenous (IV) bags is a critical aspect of healthcare, ensuring patients receive the precise medication dosage while minimizing wastage and reducing costs. The existing IV bag filling process often ...

• Small Business Lean Inventory Optimization 

  Vargas Rodríguez, Dixon Obed (Polytechnic University of Puerto Rico, 2023)

  This research investigates the problem of ineffective inventory management systems in small businesses using a qualitative case study approach. The study focuses on Dixon's Refrigeration, identifying the root causes of ...

• Design Improvement in the Workspace for Waste Reduction and Process Optimization 

  Echevarría Rosa, Veruschka N. (Polytechnic University of Puerto Rico, 2023)

  In this current project will be demonstrated how a layout in the workspace can impact the efficiency of a process. An optimal design in the location of equipment and materials needed to execute a task can reduce all those ...

• Formulation Process Optimization 

  Hernández Lorenzo, Saúl (Polytechnic University of Puerto Rico, 2023)

  The field of biologics drugs development continues to grow and is becoming increasingly competitive. The manufacturing of biological medicines is a complex process that consumes a large amount of resources and time ...

• Pull System for Material Replenishment in Manufacturing Sunshine Meds Design 

  Rivas Pagán, Samelia M. (Polytechnic University of Puerto Rico, 2023)

  This project evaluates the material replenishment for manufacturing lines in Sunshine Meds Company who prepares medical devices kits in a manufacturing cleaning room. Opportunities were found looking into the material ...

• Diseño del Área del Manejador de Materiales Utilizando la Metodología Lean 

  Medina Arroyo, Rose M. (Polytechnic University of Puerto Rico, 2023)

  En la actualidad, el área de manufactura de cierta compañía no cuenta con un área de reabastecimiento de materiales. Lo que representa que el manejador de materiales tenga que recorrer más área de la normal para poder ...

• Desarrollo de Matriz de Complejidad y Mejoras a la Matriz de Destreza para Reducir la Fatiga en el Área Laboral 

  Ponce Balaguer, Joan (Polytechnic University of Puerto Rico, 2023)

  La fatiga en el área laboral o los riesgos ergonómicos se deben principalmente a la ejecución de una estación de trabajo por un tiempo prolongado sin tener variaciones en las tareas que ejecuta. Los riesgos ergonómicos son ...

• Standardization Times in a Blending (Flex 2 Unit Operation) Manufacturing Process 

  Acevedo Colón, Gabriel (Polytechnic University of Puerto Rico, 2023)

  The continuous evolution in standardization, digitalization, and changes in the ways of working in manufacturing in the pharmaceutical industry and the increase in production for product X by 2023, has made it necessary ...

• Improvement in the Inventory System and How to Reduce Waste 

  Molina Ruiz, Eddie M. (Polytechnic University of Puerto Rico, 2023)

  Due to the recent pandemic, industries have confronted inventory problems because of all the backorders that exist with the suppliers. Consequently, industries have lacked the necessary materials to continue their processes. ...

• Chromatography Skid 3 Automation Integration Layer Upgrade 

  Figueroa Agosto, Delianne N. (Polytechnic University of Puerto Rico, 2023)

  This research will focus on upgrading the Chromatography System 3 to reduce time and generate batch reports. In this way, system monitoring is more effective and documentation is more accurate. The system handles an excessive ...

• Implementación del Parámetro Tolerancia de Proceso en el Certificado de Calibración a Instrumentos Críticos del Área de Liofilización a Través del CMMS para Reducir las Investigaciones 

  Vega Colón, Daileen (Polytechnic University of Puerto Rico, 2023)

  Los parámetros establecidos en los procesos de calibraciones son un factor crítico en la manufactura de productos farmacéuticos. A raíz de la alta incidencia de investigaciones para el departamento de calibración, se ...

• Optimization Design in the Production and Delivery Process of a Food Truck 

  Morfi Pagán, Alberto (Polytechnic University of Puerto Rico, 2023)

  This abstract provides an overview of the optimization design strategies that can improve the production and delivery process of a food truck utilizing Lean Manufacturing and DMAIC methodology. A standardized menu, quality ...

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