Control Strategy design of a Continuous Direct Compression Process for Oral Solids Dosages using Resident Time Distribution Studies

Abstract

In a continuous process any deviation from the intended process parameters can cause an unreliable product and economical losses.Residence time is a measure of how much time any given material or combination of materials spend inside a unit of a system. Residence Time Distribution (RTD) looks at the dynamics of multiple integrated units and how material properties, equipment design and process parameters impact the flow of material through the system. RTD studies for continuous manufacturing (CM) processes are used to determine the individual residence time of processing units within the system at given process conditions and equipment configuration. The RTD information can be used for material traceability, control strategy, for evaluating mixing performance, and to determine the blender noise filtering capability for the feeders’ mass flow variations.In this study, areject and accept control strategy wasdefined based on Residence Time Distribution studies.KeyTerms⎯Continuous Manufacturing, Control Strategy, Residence Time Distribution (RTD), Taylor Dispersion.