Improvement of Paterson Kelly V-Blender Ventilation System

Abstract

This paper presents the successful improvement and implementation of ventilation system modifications in a Patterson Kelly VBlender used in Upjohn (Pfizer Division) Pharmaceutical located at Barceloneta, Puerto Rico. The purpose of this research was analyzing and resolve the equipment reliability issues and flexibility generated by the introduction of new product with different formulation in the blending process. The piping changes and designed parts were made and installed by local manufacturers. Trials performed for each proposed model were performed using placebo material and executed in a pharmaceutical controlled area. Results were analyzed and documented in this paper. The research results show that the ventilation improvements preformed to the Patterson Kelly VBlender system were capable of maintain the required process parameters without interruptions. Also, provide the flexibility of the system by running products with different formulation (solvent-based and water-based product) resulting in an increase manufacturing production. Key Terms ⎯ Condenser, Dust Control, VBlender and Volatile Organic Compounds.