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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorTorres, Edgar
dc.contributor.authorVillanueva González, Rhyan S.
dc.date.accessioned2020-09-09T17:36:14Z
dc.date.available2020-09-09T17:36:14Z
dc.date.issued2016
dc.identifier.citationVillanueva González, R. S. (2016). Optimizing automated clean-in-place operations to increase productivity in a biotechnology manufacturing plant [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/541
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractAutomated Clean-In-Place Operations are an essential part of the manufacturing operations by ensuring a clean state of the equipment and/or transfer lines. However, during a voice of the customer (VOC) and value-added activities assessment, it was determined that some equipment surfaces were only exposed to salts solutions that were easy to remove. During these observations, it was evident that the clean-in-place operations needed to be optimized to increase productivity. Cleaning cycle optimization was performed under a characterization study that confirmed the effectiveness of the optimized cleaning cycle for non-product contact equipment and/or transfer lines. The optimization consisted of several rinses with purified water and a final rinse with hot water for injection (WFI). Automated recipes were modified to prevent the use of aggressive cleaning agents and/or recirculation's in the cleaning operation. The optimization of the cleaning operations increased productivity by hard savings in detergents and a significant cycle time reduction. Key Terms - Automation, Cleaning, Clean-inPlace, Cycle Time, Productivity, Savings, Water for Injection (WFI).en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Engineering;
dc.relation.ispartofseriesSpring-2016;
dc.relation.haspartSan Juanen_US
dc.subject.lcshClean rooms
dc.subject.lcshPlant biotechnology industry
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleOptimizing Automated Clean-In-Place Operations to Increase Productivity in a Biotechnology Manufacturing Planten_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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