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dc.rights.licenseAll rights reserveden_US
dc.contributor.advisorTorres, Edgar
dc.contributor.authorCabrera, Migdalis
dc.date.accessioned2020-12-10T11:34:06Z
dc.date.available2020-12-10T11:34:06Z
dc.date.issued2010
dc.identifier.citationCabrera, M. (2010). Use of experimental design for the characterization of a depyrogenation machine [Unpublished manuscript]. Graduate School, Polytechnic University of Puerto Rico.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12475/981
dc.descriptionDesign Project Article for the Graduate Programs at Polytechnic University of Puerto Ricoen_US
dc.description.abstractDepyrogenation tunnel are used in pharmaceutical filling lines to sterilize glass containers before they are aseptically filled. These tunnels use unidirectional hot air at temperatures up to 350°C and can be used to sterilize and depyrogenated glass vials and glass containers. The experimental design presented in this project describes the performance qualification activities process in the dry heat depyrogenation tunnel at worst case conditions ensuring the integrity of the HEPA filters. The parameters considered were: belt speed, temperature and endotoxin reduction. The parameters identified after analyzing the measurement are to be improved by applying DMAIC methodology from Six Sigma. Key Terms - DMAIC, experimental design, performance qualification, HEPA filters.en_US
dc.language.isoen_USen_US
dc.publisherPolytechnic University of Puerto Ricoen_US
dc.relation.ispartofManufacturing Competitiveness;
dc.relation.ispartofseriesFall-2010;
dc.relation.haspartSan Juanen_US
dc.subject.lcshExperimental designen_US
dc.subject.lcshPyrogens
dc.subject.lcshSix sigma (Quality control standard)
dc.subject.lcshAir filters
dc.subject.lcshPolytechnic University of Puerto Rico--Graduate students--Research
dc.titleUse of Experimental Design for the Characterization of a Depyrogenation Machineen_US
dc.typeArticleen_US
dc.rights.holderPolytechnic University of Puerto Rico, Graduate Schoolen_US


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